In his eleven years in San Diego, Lowe was known largely as the epitome of durability and longevity, because he missed only one game in his entire eleven-year NFL career. Moreover, despite his skills in defending the run, Lowe was particularly adept as a pass defender, which is a bit of a rarity for a linebacker. All told, Lowe racked up 21 interceptions as a Charger, and 4 were returned for a touchdown.
After retiring from the NFL, Lowe became a football coach. He spent six years in the NFL as a defensive assistant for the Oakland Raiders and the Kansas City Chiefs, and eventually returned to his alma mater as an assistant coach, a stint which included the Red Devils' 1993 state championship. After spending five years with the UAB Blazers, Lowe moved back to the high school ranks and became the head coach for Central's biggest rival, Smiths Station High School. Lowe was removed from his position at Smiths Station by the Lee County Board of Education in 2008 after compliling a total record of 12 wins and 19 losses in only 3 years as head coach. Lowe was an assistant coach at Jackson-Olin High School in Birmingham.
On December 30, 2009 Lowe was named the head coach and returned home to his alma mater, Central High School in Phenix City, AL.