Hopkins was drafted by the Eagles in the second round of the 1983 NFL Draft and started 14 games at free safety as a rookie. In 1985, he had a career-high 6 interceptions (including one for a touchdown) was voted Most Valuable Player on the Eagles defense and was selected to the Pro Bowl. In 1988, he was voted the Eagles Ed Block Courage Award winner. As part of the Eagles vaunted "Gang Green" defense, the safety tandem of Hopkins and strong safetyAndre Waters lasted from 1986 to 1993. With Buddy Ryan as head coach from 1986 to 1990, the tandem were considered one of the hardest hitting and most feared safety duos in the NFL. Hopkins retired after the 1993 season and finished his career with 30 interceptions, 12 sacks and 1 touchdown.