Jurgensen was born in Wilmington, North Carolina. He became active in sports as early as elementary school, when he led his school to the city grammar school titles in baseball and basketball. He later captured the boys tennis championship of Wilmington and pitched for his local Civitan club, who won the city baseball title.
"Jurgensen was a rugged boy and could have been outstanding at center, guard, end or any backfield position."
Jurgensen's high school football coach, Leon Brogden.
Jurgensen also played basketball and baseball during high school. As a senior on the basketball team, he averaged twelve points per game as a guard and the team was the state title runner-up. That same year in baseball, he batted .339 and played as a pitcher, infielder, and catcher. He also became a switch-hitter.
Jurgensen attended and played college football at Duke University. He joined the varsity team in 1954 as a backup quarterback behind Jerry Barger and he completed 12 of 28 passes for 212 yards, with one touchdown and three interceptions.
Jurgensen took over as starting quarterback in 1955. He also retained a starting position in the defensive secondary.
Duke ended the season with a 7–2–1 record along with an ACC co-championship, but did not go to a bowl because Maryland received the league's automatic bid to the Orange Bowl. That season Jurgensen completed 37 of 69 passes for 536 yards, three touchdowns and seven interceptions. He rushed 54 times for 48 yards and scored two touchdowns. He also punted four times for a 33.7 average and intercepted four passes for 17 yards.
Jurgensen's senior season in 1956 did not start well, when Duke lost to South Carolina, 7–0, in the season opener. This game marked Duke's first ACC loss, coming in the fourth year of the conference's existence. Duke finished the season with a 5–4–1 mark and Jurgensen ended up 28–59 for 371 yards.
He threw six interceptions and two touchdown passes and rushed 25 times for 51 yards with three touchdowns. Jurgensen's final career stats included 77–156 passes for 1,119 yards, 16 career interceptions and six touchdowns. He also rushed for 109 yards and intercepted 10 passes.
Jurgensen also played baseball briefly at Duke, but turned down an invitation to try out for the basketball team.
"All I ask of my blockers is four seconds. I try to stay on my feet and not be forced out of the pocket. I beat people by throwing, not running. I won't let them intimidate me into doing something which is not the best thing I can do."
After Van Brocklin retired in 1961, Jurgensen took over as Philadelphia's starter and had a successful year, passing for an NFL record 3,723 yards, tying the NFL record with 32 touchdown passes, and was named All-Pro. Following an injury-plagued 1963 season, Jurgensen was traded to the Washington Redskins on April 1, 1964 in exchange for quarterback Norm Snead and cornerbackClaude Crabb.
In 1967, Jurgensen broke his own record by passing for 3,747 yards and also set NFL single-season records for attempts (508) and completions (288). He missed much of the 1968 season because of broken ribs and elbow surgery. He did, however, tie an NFL record early in the 1968 season for the longest pass play in NFL history. The 99-yard pass play to Jerry Allen occurred September 15, 1968 during the Redskins' game against the Chicago Bears. Coincidentally, Redskins' quarterbacks had three of the first four occurrences of a 99-yard pass play (Frank Filchock to Andy Farkas in 1939 and George Izo to Bobby Mitchell in 1963 were the other two occurrences of the play). Since Jurgensen's feat, no other Redskins' quarterback has completed a 99-yard pass.
"Jurgensen is a great quarterback. He hangs in there under adverse conditions. He may be the best the league has ever seen. He is the best I have seen."
In 1969, Vince Lombardi took over as the Redskins' head coach. That season, Jurgensen led the NFL in attempts (442), completions (274), completion percentage (62%) and passing yards (3,102). The Redskins went 7–5–2 and had their best season since 1955 (which kept Lombardi's record of never having coached a losing NFL team intact). Sadly, Lombardi died of cancer shortly before the start of the 1970 season. Jurgensen would later say that, of the nine head coaches he played for during his NFL career, Lombardi was his favorite.
During this period, a quarterback controversy developed between the two, complete with fans sporting "I Love Billy" or "I Love Sonny" bumper stickers on their vehicles. The defensive-minded Allen preferred Kilmer's conservative, ball-control style of play to Jurgensen's more high-risk approach. Despite the controversy, Jurgensen was helpful to his rival. Even to this day, Kilmer still stays at Jurgensen's house when he is in town.
In 1974, at the age of 40 and in his final season, Jurgensen won his third NFL passing crown even though he was still splitting time with Kilmer. In what would be the final game of his NFL career, Jurgensen made his first and only appearance in an NFL postseason game in the Redskins' 19–10 loss to the Los Angeles Rams in the first round of the 1974 NFC playoffs. He came off the bench in relief of Kilmer and completed six of 12 passes but also threw three interceptions.
Jurgensen is recognized as the finest pure passer of his time. A five-time Pro Bowl selection, he earned three NFL individual passing titles. He exceeded 400 yards passing in a single game five times, and threw five touchdown passes in a game twice. With a career rating of 82.6, his stats include 2,433 completions for 32,224 yards and 255 touchdowns. He also rushed for 493 yards and 15 touchdowns.
Jurgensen's 82.62 career passer rating is the highest for any player in the "Dead Ball Era" (pre-1978).
After retiring from the Redskins' following the 1974 season, Jurgensen began another career as a color commentator, initially with CBS television. Later teaming with Hall of Fame linebacker Sam Huff, Jurgensen continues to cover the Washington Redskins on radio. On a 2006 NBC 4 broadcast with George Michael, Jurgensen said in his prime he was able to throw the ball 80 yards.
He covered the team for NBC 4 from 1994 until December 2008, when Redskins Report was canceled due to budget cuts. He served as a game analyst at preseason games and as studio analyst at training camp, making weekly picks, and other assignments.