Lockette was signed by the Seattle Seahawks as an undrafted free agent following the end of the NFL lockout in 2011. He was released on September 3, and re-signed to the Seahawks' practice squad the following day. On December 14, 2011, Lockette was promoted to active 53-man Seattle Seahawks' roster.
Lockette is best known for his critical 44 yard reception in a close loss to division rival San Francisco 49ers on December 24, 2011, as well as a 61 yard touchdown grab in an overtime loss to another rival, the Arizona Cardinals on January 1, 2012.
Lockette was cut during final roster cuts after the 2012 preseason. He was signed to the practice squad, but was released on September 18. Lockette signed with the San Francisco 49ers on September 24, 2012.