In the aftermath of his All-American junior season and the Gators' Bowl Alliance national championship victory over the Florida State Seminoles in the Sugar Bowl, Anthony decided to forgo his final season of NCAA eligibility and enter the NFL Draft. He finished his college career with 126 receptions for 2,274 yards and twenty-six touchdowns (a career average of 18.0 yards per reception). His eighteen receiving touchdowns in 1996 remains the SEC and Gators' team record.
In a 2006 series written for The Gainesville Sun, Anthony was recognized as No. 17 among the 100 all-time greatest Gators of the first 100 years of Florida football. He was inducted into the University of Florida Athletic Hall of Fame as a "Gator Great" in 2009.
The Tampa Bay Buccaneers chose Anthony in the first round (sixteenth pick overall) of the 1997 NFL Draft, and he played for the Buccaneers for five seasons from 1997 to 2001.
In 1997, Anthony recorded thirty-five receptions for 448 yards and four touchdowns. In his first game, Anthony became (and still remains) the youngest NFL player ever to record a touchdown reception (20 years, 315 days). In 1998, he set career highs with fifty-one receptions for 708 yards and seven touchdowns. In perhaps his finest game as a Buccaneer, Anthony recorded 126 receiving yards with two touchdowns against the Jacksonville Jaguars on November 15, 1998. During the year, he also finished eighth in the NFL in all-purpose yards, totaling 1,869 yards. In 1999, Anthony had thirty receptions for 296 yards, and scored one touchdown. In 2000, Anthony had fifteen receptions for 232 yards and four touchdowns. In his final NFL season in 2001, he recorded thirteen receptions for 162 yards.
Anthony finished his five-year NFL career with 144 receptions for 1,846 yards and sixteen touchdowns.
Anthony currently is the offensive coordinator at his alma mater, Glades Central High School in Belle Glade, Florida. He was formerly the receivers coach for the Celtics football team of Trinity Catholic High School in Ocala, Florida. He is also a contributing writer to the ESPN-affiliated fan site GatorCountry.com as its official offensive analyst.