He played college football at North Carolina State University. A surprise 1st round pick by the Eagles in the 1982 NFL Draft, Quick developed into a five-time Pro Bowler, having been selected consecutively from 1983 to 1987. He led the NFL in receiving yards in 1983 with 1,409 and finished second in 1985 with a total of 1,247. On November 10, 1985, Mike Quick caught a 99-yard touchdown pass from Ron Jaworski in overtime (an Eagles team record, and tied with eleven other QB-WR combos as an NFL record), as the Eagles beat the Atlanta Falcons in the game. He retired due to severe patella tendinitis.