He played college football at North Carolina State University. A surprise 1st round pick by the Eagles in the 1982 NFL Draft, Quick developed into a five-time Pro Bowler, having been selected consecutively from 1983 to 1987. He led the NFL in receiving yards in 1983 with 1,409 and finished second in 1985 with a total of 1,247. On November 10, 1985, Mike Quick caught a 99-yard touchdown pass from Ron Jaworski in overtime (an Eagles team record, and tied with eleven other QB-WR combos as an NFL record), as the Eagles beat the Atlanta Falcons in the game. He retired due to severe patella tendinitis.
He is currently a color commentator for Philadelphia Eagles radio broadcasts on WIP 610 AM and 94.1 FM along with Merrill Reese. Quick now resides in Marlton, New Jersey with his sons, Ronson, who plays basketball at Assumption College, and Stephen.