A graduate of Cardinal Newman Secondary School, where he earned athlete of the year honours and was football MVP twice, Morreale played his university football with the McMaster University Marauders from 1991 to 1994. He finished his Marauder career with 116 receptions for 1,880 yards and a school record 16 touchdowns and had 217 yards on 27 punt returns and 185 yards on nine kickoff returns. He also carried the ball four times for 33 yards and averaged 33.7 yards on 36 punts. He was a CIAU second team All-Canadian once and a two-time OUAA All-Star at wide receiver. He was named to the McMaster Hall of Fame in 2005 and a member of the McMaster University Football Team of the Century.
He was the CFL spokesman for the War Amps Champs program in 1997 and raised $26,000 for Hamilton Children's Hospital in the 1999 Morreale Macaroni campaign. He is also a first cousin of Toronto Argonauts legend Paul Masotti.
Mike Morreale and fellow Hamilton, Ontario native linebacker Rob Hitchcock, were released from the Hamilton Tiger-Cats on June 19, 2007. He officially announced his retirement on August 27, 2007 and joined the McMaster University coaching staff as Quality Control Manager, Offence and Special Teams. He was honoured by the Tiger-Cats at a halftime ceremony during the 2007 Labour Day Classic along with Rob Hitchcock
Currently, Morreale is the President of the Canadian Football League Players' Association after spending the last 5 years as ithe Director of Marketing .