Sanzotta played professional football in the National Football League (NFL) for the Detroit Lions in 1942 and 1946. He was the Lions' leading rusher in 1942 with 268 rushing yards on 71 carries.[2] He missed the 1943 to 1945 seasons while serving in the Navy during World War II.[3] He played for the Naval Air Technical Training Center Raiders football team in 1943.[4]