Amedee played quarterback and placekicker under coaches Paul Dietzel and Charles McClendon at Louisiana State from 1960–1962. He was not drafted in the 1963 NFL Draft but started a pro career with the Edmonton Eskimos. From 1963 to 1964, Amedee played in 16 games for the Eskimos. Over the course of the two seasons, he threw for 1,788 yards on 279 attempts with eight touchdowns. Later Amedee started a coaching career, returning to his alma mater as quarterbacks coach under head coach McClendon from 1975 to 1978.
In 1989 Amedee was hired as offensive coordinator by Texas head coach David McWilliams. After McWilliams resignation in 1991, Amedee sat out for a year, before joining Curley Hallman's coaching staff at his alma mater LSU. Hallman, along with the coaching staff, was fired after the 1994 season. Amedee went on to coach one season at New Iberia (Louisiana) Senior High, and left the school that December to accept the offensive coordinator position under Sherrill at Mississippi State. In 1999, Amedee left the collegiate ranks, taking over head coaching duties at Opelousas High School in Opelousas, Louisiana, he retired after the 2003 season.