Sitton attended Catholic High School in Pensacola, Florida, where he lettered four times in football and twice in basketball. A two-way lineman, Sitton allowed just three quarterback sacks over two seasons on the offensive side, while adding 50 tackles and six sacks as a defensive lineman as a senior. He earned second-team all-state and first-team all-area honors as an offensive lineman as a senior.
In his true freshman season at UCF, Sitton played in all 11 games with four starts at right guard. He was moved to right tackle for his sophomore season, where he started all 13 games for the Knights. He remained a starter at right tackle for the rest of his college career, blocking the way for Kevin Smith, as he rushed for 2,567 yards in 2007, just 62 yards short of breaking Barry Sanders' NCAA single-season rushing record (2,628) set in 1988.