2006–07 was another season of change for the GSC. Central Arkansas moved to Division I, leaving the West Division with eight schools while Lincoln Memorial left for the South Atlantic Conference due to travel and location issues, leaving the East Division with seven schools.
Montevallo announced on June 27, 2008 that they will be leaving for the Peach Belt Conference following the 2008–09 season due to issues between the University's President and the Commissioner.
Beginning with the 2011–12 academic year, current GSC members University of Arkansas at Monticello, Arkansas Tech University, Harding University, Henderson State University, Ouachita Baptist University and Southern Arkansas University left the GSC to form the Great American Conference.
The University of New Orleans, which was transitioning from Division I to Division II, was accepted into the conference in June 2011, but the school announced intentions to stay Division I in March 2012. In July 2011, Shorter University and Union University (Jackson, Tenn.) were accepted into the NCAA and will begin the multi-year transition process from the NAIA to NCAA. Both universities will begin GSC competition in the 2012–13 academic year but will not be eligible for NCAA national tournaments until the 2014–15 academic year. In August 2011, the GSC added the Florida Institute of Technology as an associate member for football beginning in the 2013 season.
On October 11, 2012, Mississippi College announced that it would petition the NCAA to leave Division III and return to the conference.
1 - New Orleans was a provisional member in the GSC, which was transitioning from Division I to Division II, competing in volleyball, baseball, men’s & women’s cross country, men’s & women’s golf, and men’s & women’s tennis. However, the school announced intentions to stay Division I as of March 2012.
GSC members feature comprehensive athletic programs that compete for 14 official conference championships: football, men’s and women’s cross country, men’s and women’s soccer, women’s volleyball, men’s and women’s basketball, baseball, softball, men’s and women’s tennis and men’s and women’s golf.
The GSC is perhaps best known for being the premier conference in NCAA Division II football. The three-year run put together by North Alabama in the mid-1990s is one of the most amazing feats in college football history. North Alabama went 41-1 during that span with the only loss being a 3 point loss to that season’s NCAA Division I-AA champion Youngstown State.
^A Valdosta State was not a member of the GSC in 1979.
^B Although not a conference-sanctioned sport, Alabama–Huntsville fields a men's ice hockey team. It won the Division II national championship in 1996 and 1998. After the NCAA discontinued Division II ice hockey championship, UAH moved to Division I for that sport and joined the College Hockey America conference. They now compete as an independent after the demise of the CHA but will join the Western Collegiate Hockey Association prior to 2013-2014.