Frank G. Anderson (May 24, 1928 in Oklahoma City, Oklahoma — September 28, 1983 in Edmonton, Alberta) was a professional Canadian football player who played college football for the Oklahoma Sooners from 1947 to 1950. Anderson played under legendary college football coach Bud Wilkinson. The Sooners, from 1947 to 1950, lost only three games. The first in 1948, undefeated in 1949, losing the Sugar Bowl in 1951 following the 1950 season. The Sooners won consecutive Sugar Bowl Championships in 1949 and 1950. Anderson was named All-American in 1950.

Anderson joined fellow Sooner quarterback Claude Arnold in Edmonton for the 1952 season. Anderson played from 1952 to 1957 with the Edmonton Eskimos, during which time, he earned the nickname "Blood & Guts" for his tough on field performance. During his time with the Eskimos, Frank was a 5-time defensive All-star. Also during his tenure, the Eskimos played in the 1952 Grey Cup, losing to the Toronto Argonauts. From 1954 through 1956, the Eskimos won three Grey Cups in a row; all were played against the Montreal Alouettes led by legendary quarterback Sam 'The Rifle' Etcheverry. Anderson was inducted (posthumously) onto the Commonwealth Stadium Wall of Honour in October 1985, the 8th former player honored.

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