Wycoff was a prominent fullback for Bill Alexander's Georgia Tech Yellow Jackets football team from 1923 to 1925. He was elected captain of the 1925 team, having been "the outstanding back of the South for the past two years." Coach Alexander recalled "The work of Douglas Wycoff against Notre Dame two years in succession was brilliant in the extreme, as was his plunging against Penn. State when we defeated them twice." He was a consensus All-Southern choice each year he played. Lawrence Perry selected Wycoff first-team All-American in 1924.
Morgan Blake, sports writer for the Atlanta Journal, said of an all-time All-Southern list: "It seems to us that one name is left out in this collection, who may have been the best all-around player the South has had.
"We have reference to Doug Wycoff of Tech who, for three straight years, was practically the unanimous all-Southern football choice, despite the fact that Georgia Tech had very lean years during his period of play at this institution. If Wycoff had been flanked by such a pair of halfbacks as Red Barron and Buck Flowers, or Thomason and Mizell while he was with the Jackets, he would have been an all-American. As it was he had to carry all of the offensive load and on the defense he was a wheelhorse. He was a great punter and passer. If Wycoff was not the best all-around player the South had produced then he was very close to the peak."
Wycoff also wrestled. He once beat former Florida Gators fullback Bill Middlekauff in a match, the main event at the Atlanta Municipal Auditorium for Georgia Championship Wrestling promoter Henry Weber.