Nickey attended Jonathan Alder High School in Plain City, Ohio, and wore number 2, and was an All-Ohio running back. He also played free safety in football. In addition to his football talent he was selected as an All-State center fielder as part of the 1998 OHSAA State Championship team (baseball).
Nickey was drafted by the Tennessee Titans in the 5th round (19th pick) of the 2003 NFL Draft. He played his entire career with the Titans. Most of his time playing time logged on special teams, where he had been label as an 'Ace'.
In 2010, while with the Titans, Nickey was ejected from a game against the San Diego Chargers after he shoved an official in the back during a retaliation with Chargers player Scott Mruczkowski.
He was released by the Titans on July 25, 2011 after spending 8 seasons with the team.