After turning pro, Noble signed with the NFL's Cleveland Bulldogs for 1924. On October 12, he scored his first NFL touchdown in a Bulldogs win against the Akron Pros. Playing in all nine of the team's games, and starting in eight, he totalled four rushing and two receiving touchdowns, helping the 7–1–1 Bulldogs win the NFL championship. For his performance, Noble was named to the All-NFL second team after the season. In 1925, Noble earned NFL All-Pro honors after recording three rushing and three receiving touchdowns during the season; he started all but one game in Cleveland's 5–8–1 season.
The following year, Noble stayed in Cleveland but changed teams, playing for the Cleveland Panthers of the new AFL. In
five games, Noble helped the Panthers finish with a final record of 3–2 and was tied for second in the league in rushing touchdowns with four, despite his team's limited schedule. He also caught one touchdown pass. It would prove to be Noble's final professional season.
Following his playing career, Noble became an official and worked for the Big Ten Conference. In later years, he became an executive for an insurance company. In 1972, Noble was inducted into the Nebraska Football Hall of Fame. He suffered a stroke on January 24, 1983, and died at the age of 82.