Enis attended Pennsylvania State University, where he majored in recreational management and played for coach Joe Paterno's Penn State Nittany Lions football team from 1995 to 1997. Following his junior season in 1997, he was recognized as a consensus first-team All-American.
Enis initially held out and ended up missing 26 days of training camp and 2 exhibition games after being drafted by the Chicago Bears with the 5th overall pick.
Enis made just one start before tearing a ligament in his left knee in November 1998. His career in Chicago was largely defined by struggling to stay on the field as a result of injuries, and by poor production when he did play. By 2000, Enis had been supplanted by James Allen and was being utilized as a FB. In three years, he played 36 games, accumulating 1,497 rushing yards and 4 touchdowns.
In 2001, at the age of 24, Enis signed a one-year deal with the Cleveland Browns, but a degenerative condition in his left knee forced him into retirement.