As a redshirt freshman, Fajardo became the starting quarterback for 2011 Nevada Wolf Pack football team. Playing against Texas Tech in the third game of the 2011 season, Fajardo rushed for 139 yards and two touchdowns on 10 carries and completed four of six passes for 59 yards and a touchdown. On October 15, 2011, he led the Wolfpack to a 49–7 win over New Mexico, running for two touchdowns and completing 20 of 25 passes for 203 yards. He finished 2011 with 1,707 passing yards, 6 passing touchdowns and 694 rushing yards and 11 rushing touchdowns.
Fajardo had 2,786 passing yards, 20 passing touchdowns, 1,121 rushing yards, and 12 rushing touchdowns. In 2013, he passed 2,668 yards, 13 passing touchdowns, 621 rushing yards and eight touchdowns. As a senior in 2014, he passed for 2,498 yards, 18 passing touchdowns and rushed for 1,046 yards and 13 touchdowns.
Fajardo is one of only two players in NCAA history with 9,000 yards passing and 3,000 yards rushing. The other being Colin Kaepernick. Both are Nevada Alums. Fajardo also accounted for 101 touchdowns in his career at Nevada.
Fajardo met his wife, Laura Voss now Laura Fajardo, while playing football at Nevada. They got married in Reno, NV on March 16, 2019.
On October 8, 2015, Fajardo was signed to the practice roster of the Toronto Argonauts of the Canadian Football League. He re-signed with the Argonauts on May 17, 2016. Fajardo scored his first professional rushing touchdown on July 13, 2016 before throwing his first professional touchdown pass on July 25, 2016. Fajardo would see his role expand during 2017 into a change-of-pace backup while starter Ricky Ray sat out with injury, but remained the short yardage quarterback when Ray returned. He scored the game-winning touchdown with 23 seconds remaining in the 2017 East Final in short-yardage, on a 1-yard plunge, sending the Argonauts to the 105th Grey Cup game. The Argos would go on to win the championship game over the Calgary Stampeders. Although Fajardo showed considerable promise and poise when he played, the Argonauts were unable to sign him to a contract extension with the acquisition of James Franklin from the Edmonton Eskimos.
After failing to sign with the Argonauts and entering Free Agency, Fajardo signed with the BC Lions on February 16, 2018. Fajardo continued his role as a short down rusher and change of pace quarterback behind Travis Lulay and Jonathan Jennings, registering 14 completions on 20 attempts for 153 yards, one touchdown and one interception, as well as 42 rushes for 108 yards and 5 more scores. During the Lions' 2018 Eastern Conference semifinal loss to the Hamilton Tiger-Cats Fajardo failed to execute a quarterback sneak, leading some to speculate that we had seen the last of him in the CFL.
On the third day of free agency, Fajardo signed with the Saskatchewan Roughriders on a one year contract, joining a quarterback room featuring Zach Collaros and David Watford. Fajardo became the starting quarterback following an injury to Collaros in the opening game of the season. He lead the team to a win on July 1, 2019 throwing for 430 yards against the Toronto Argonauts. Fajardo continued to play well in the following weeks which prompted the Roughriders to trade Collaros to the Argonauts, solidifying their trust in Fajardo.