|Athletic director||Brian Chafin|
|Head coach||Andrew M. Frye|
|Home stadium||Cheek Field and Farris Stadium|
|Stadium surface||Field Turf|
|Conference||Southern Athletic Association (SAA)|
|Past conferences||Southern Intercollegiate Athletic Association (1911–1941)|
Southern Collegiate Athletic Conference (1962–2011)
|Postseason bowl record||2–1–0|
|Claimed national titles||1|
|Conference titles||11 SCAC, 1 SIAA|
|Colors||Gold and White|
The Centre Colonels football team, historically also known as the Praying Colonels, represents Centre College in National Collegiate Athletic Association (NCAA) Division III competition. The Colonels currently play in the Southern Athletic Association (SAA), which played its first season in 2012 after its formation in 2011 by a group of schools that included Centre. Before the establishment of the SAA, Centre had played 50 seasons in the Southern Collegiate Athletic Conference. Despite the school's small size (2008 enrollment of 1,215), the football team has historically had success and possesses a strong tradition. At the end of the 2008 season, the school ranked as the 12th winningest school in Division III with an all-time record of 509–374–37.
On April 9, 1880, a Centre College team traveled to Lexington to play against Kentucky in the first football game south of the Ohio River. The Colonels lost that game, and a rematch at home later in the month, but it was the start of a long-running rivalry with their in-state opponent. The first officially recognized Centre–Kentucky game took place in 1891. In that series, the Colonels compiled a 18–12–2 record before the Kentucky athletic council determined to permanently drop Centre from their schedule.
From 1917 to 1924, Centre compiled a 57–8 record while playing against some of the best teams in the nation. After the 1920 season, Centre faced Texas Christian (TCU) in the Fort Worth Classic. The Colonels convincingly routed them, 63–7.
The 1921 Centre–Harvard game resulted in one of the most shocking upsets in college football, with the Colonels winning, 6–0. The star of that game, back Alvin "Bo" McMillin, was twice named a consensus All-American, in 1919 and 1921. Center James Weaver was named a consensus All-American alongside him in 1919. The Colonels finished the 1921 season undefeated, having outscored their opponents, 314 points to 6. In the Dixie Classic, precursor to the modern Cotton Bowl Classic, Centre faced Texas A&M. Miscues contributed to the Colonels' defeat, 22–14. This is also the game in which Texas A&M's 12th man tradition originated.
Centre again found success during the 1950s. In 1951, the Colonels finished the season with a 5–1 record and were invited to play Northern Illinois State in the Corn Bowl. The invitation, however, was rejected by the school administration who wished to de-emphasize football. From 1954 to 1956, Centre compiled a sixteen-game winning streak. In 1955, the undefeated Colonels were again invited to a postseason game, the Tangerine Bowl, but once more declined.
In recent years, Centre has secured eight SCAC championships between 1980 and 2003. Jack "Teel" Bruner, a safety from 1982 to 1985, became the second Centre Colonel inducted into the College Football Hall of Fame. In 1984, he recorded five interceptions against Rose-Hulman, tying the all-time record.
In 2011, the Colonels' final SCAC season, they finished second in the conference, but received an at-large invitation to the NCAA tournament. The Colonels defeated Hampden–Sydney in the first round to earn their first Division III tournament win, and lost in the next round to traditional D-III powerhouse Mount Union.