Guy hails from Ellwood City, Pennsylvania where he played for the Lincoln High School Wolverines. Following graduation in 1954, he attended Duke University where he played college football. According to his obituary, he was known as Buster in high school, a more fitting name for a star athlete than "Melwood from Ellwood". Later Buster was shortened to Buzz because Duke athletics eschewed multisyllabic monikers in the 1950s.
He was an offensive lineman that alternated between guard and tackle. He saw action in the 1955 Orange Bowl in which the Blue Devils rolled over the NebraskaCornhuskers 34–7. Following the game, Nebraska Head Coach Bill Glassford singled out the play of Duke's offensive line as the key to the game, saying, "That Duke line outcharged us". He left school with one year remaining of eligibility to join the NFL.