During his tenure with the Lions, Ramsey is credited with devising the 4-3 defense, a staple of modern football, and being the first coach to blitzlinebackers, a package he called Red Dog. The Lions won three World Championships in the 1950s with Ramsey running the defense. He developed Lions greats such as Yale Lary, Jack Christiansen, Jim David, and many others. In 1960, he was lured to the new AFL as coach of the Buffalo Bills. Though fired by Bills' owner Ralph C. Wilson Jr. after the 1961 AFL season, Ramsey is credited for laying the foundation of one of the best defensive teams in the history of the AFL. He also had a brother, Knox Ramsey, who also starred for the College of William and Mary, the Chicago Cardinals, and the Washington Redskins. Ramsey was elected into the College Football Hall of Fame in 1978.