Andre Smith may refer to:
- J. Andre Smith (1880–1959), American war artist
- Andre Smith (offensive tackle) (born 1987), American football offensive tackle for the Cincinnati Bengals
- Andre Smith (tight end) (born 1988), American football tight end for the Indianapolis Colts
- Andre Smith (Nebraska basketball), American basketball player known for his career at the University of Nebraska–Lincoln
- Andre Smith (basketball, born 1985), American expatriate professional basketball
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