On November 8, 1905, Barlow was Michigan's starting quarterback in a 40 to 0 victory over Ohio State. The game featured a 105-yard run by Barlow, described as "the longest ever seen on Ferry Field." Barlow returned a missed dropkick from five yards deep in Michigan's endzone. Almost tackled at the 40-yard line, Barlow was aided by his teammates' blocking and returned the ball all the way for a touchdown. The Detroit Free Press reported the length of Barlow's (described by the Free Press as "little Al Barlow") run as 110 yards and noted that "2,000 Michigan rooters rose and cheered wildly as Barlow planted ball behind the enemy's goal, after his record run."