Born near Embreville, Pennsylvania, he attended public schools in Romansville, Pennsylvania and the West Chester Normal School for three years. He graduated from the law department of the University of Michigan, at Ann Arbor, Michigan in 1893 and was admitted to the bar in the same year. He set up practice in Omaha, Nebraska.
He was a member of various Republican State and county committees. He was assistant county attorney for Douglas County, Nebraska from 1896 to 1898. He ran in 1908 for the Sixty-first United States Congress and lost. He then became chairman of the Republican State convention in 1910. He succeeded in being elected to the Sixty-sixth and Sixty-seventh Congresses serving from March 4, 1919 to March 3, 1923. He ran unsuccessfully for the United States Senate in 1922 against Robert Beecher Howell.
He resumed the practice of law in Omaha. He was elected delegate at large to the 1924 Republican National Convention. He was also the manager of the Coolidge-Dawes automobile caravan from Plymouth, Vermont to Bellingham, Washington. He resumed his practice of law in Omaha, trying once more unsuccessfully candidate for United States Senator in 1940. He failed to get the nomination. He died at Omaha, Nebraska on September 14, 1942 and is buried in Forest Lawn Cemetery, Omaha.
- "The Political Graveyard". Jefferis, Albert Webb. Archived from the original on 6 February 2006. http://web.archive.org/web/20060206152953/http://politicalgraveyard.com/bio/jasen-jeffreys.html. Retrieved February 1, 2006.
- "Congressional Bioguide". Jefferis, Albert Webb. http://bioguide.congress.gov/scripts/biodisplay.pl?index=J000067. Retrieved February 1, 2006.
- Albert W. Jefferis at the Biographical Directory of the United States Congress