The 46th Vanier Cup took place on November 27, 2010, at PEPS Stadium in Quebec City, Quebec, determining the CIS Football champions for 2010. The Laval Rouge et Or defeated the Calgary Dinos 29–2 to win their sixth national title in twelve years. Including the playoffs, the Rouge et Or won thirteen games, a single season record. Laval's defence held Calgary to 147 yards on offence; the Dinos' only points came on a conceded safety in the second quarter.
Sébastien Lévesque won the Ted Morris Memorial Trophy as Most Valuable Player, rushing for 168 yards and one touchdown. On defence, the Bruce Coulter Award went to Marc-Antoine Beaudoin-Cloutier, who recorded 4.5 tackles and a sack.
In what was statistically the most commanding defensive effort in Vanier Cup history, the Rouge et Or held the Dinos offence to just 140 net yards, bettering the previous Vanier Cup mark of 161 net yards allowed by the Guelph Gryphons in their 1984 victory over the Mount Allison Mounties.
Laval won a third Vanier Cup against head coach Blake Nill. The first two occurrences happened in 1999 and 2003 while Nill was coaching the Saint Mary's Huskies.
After their win, the Laval Rouge et Or have now won six national titles, tied for first overall with the Western Ontario Mustangs. However, Laval is undefeated in six games, whereas Western has won six games and lost six games.
With this title, Glen Constantin becomes the first to win 5 Vanier Cup titles as head coach. Peter Connellan, former Calgary head coach, comes second with 4 wins.
The Vanier Cup is played between the champions of the Mitchell Bowl and the Uteck Bowl, the national semi-final games. In 2010, according to the rotating schedule, the Dunsmore Cup Quebec championship team will meet the Ontario conference's Yates Cup champion for the Uteck Bowl. The winners of the Canada West conference Hardy Trophy will host the Atlantic conference Loney Bowl champions for the Mitchell Bowl.