Ole Miss has the distinction of playing in the last ever Cotton Bowl Classic held in the old Cotton Bowl stadium and playing in the first ever Cotton Bowl Classic held in its new home at Cowboys Stadium.
This was also the second meeting between Ole Miss and Oklahoma State in a Cotton Bowl Classic game. The two teams met in the 2004 Cotton Bowl Classic, which Ole Miss won 31-28 on the arm of quarterback Eli Manning.
This was Oklahoma State's third appearance in the Cotton Bowl Classic. Their first was a 34–0 win over TCU in 1945. This was Ole Miss' fifth appearance in the Cotton Bowl Classic. Aside from the 2004 and 2009 games, Ole Miss defeated TCU 14–13 in 1956 and lost to Texas 7–12 in 1962.
In this 2010 edition of the Cotton Bowl Classic, Ole Miss defeated Oklahoma State by a score of 21-7. With the win, Ole Miss became the first team to win back-to-back Cotton Bowl Classics since Notre Dame did so in 1993 and 1994. Ole Miss' Dexter McCluster was awarded the offensive MVP, making him only the second back-to-back offensive MVP in the Cotton Bowl Classic's 74 year history. The other was SMU's Doak Walker in 1948 and 1949. McCluster's 86-yard run for a touchdown was the longest actual completed run in Cotton Bowl Classic history but is not the longest officially. In the 1954 Cotton Bowl Classic, Rice University's Dicky Moegle began a run from his team's 5 yard line down the sideline near the University of Alabama's bench. As Moegle passed Alabama's bench, Alabama player Tommy Lewis jumped off the bench, wearing no helmet, and tackled Moegle at the 42-yard line. The referee saw what happened and signaled touchdown therefore making it officially a 95-yard run for a touchdown.