Northwestern's Brian Peters intercepted Missouri quarterback Chase Daniel on the Tiger's first drive. The Wildcats took advantage of the mistake and quarterback C.J. Bacher found a wide-open Eric Peterman for a 35-yard touchdown.
Missouri and Northwestern traded field goals in the second quarter. With just one minute before halftime, Jeremy Maclin bolted for a 75-yard punt return for a touchdown.
Bacher found Rasheed Ward for a 46-yard touchdown pass on the first drive of the second half. However, NU's extra point attempt bounced off the right upright, making the score 16-10 NU. Danario Alexander gave Mizzou its first lead of the game with an 11-yard touchdown pass from Daniel with about 7 minutes left in the third. Missouri kicked another field goal later in the quarter. With 31 seconds left in the quarter, Bacher found Ross Lane in the back of the endzone to give Northwestern a 23-20 lead.
Jeff Wolfert made his third field goal of the game with 2:49 remaining to tie the game at 23-all. However, he would miss a 44-yard field as time expired, sending the game into overtime.
Missouri started on offense first to begin the overtime period. Chase Daniel threw a 7-yard pass to Maclin to give Missouri a 30-23 lead. Like their offense, Missouri's defense delivered. They forced a back-pedaling Bacher to fumble the ball, leaving Northwestern with a fourth-and-goal from the 32-yard line. Bacher's desperation hail mary was knocked down into the end zone.