† – BCS representative as champion x – Division champion/co-champions Rankings from AP Poll
The Big 12 North representative was the Nebraska Cornhuskers. The team was coached by Bill Callahan, in his third season at Nebraska. Nebraska played their home games at Memorial Stadium. Quarterback Zac Taylor in his senior year led the Huskers to an undefeated record against Big 12 North opponents. The Huskers ended the regular season with a record of 9-3 (6-2, Big 12), with losses coming to USC, Texas, and Oklahoma State.
The Big 12 South representative was the Oklahoma Sooners. The team was coached by Bob Stoops, in his eighth season at Oklahoma. Oklahoma played their home games at Gaylord Family Oklahoma Memorial Stadium. The Sooners ended the regular season with a record of 10-2 (7-1, Big 12), with losses coming to Oregon and Texas.
The Sooners went on to play in the Fiesta Bowl and lose to Boise State Broncos in one of the most historic upsets in BCS and bowl game history, not only because of the winner, but the way in which Boise State used a trick play to win the game.