The 2001 edition to the Humanitarian Bowl was the 5th edition of the bowl game. It featured the Clemson Tigers, and the Louisiana Tech Bulldogs.
Louisiana Tech scored first on a 29 yard field goal from placekicker Josh Scobee, giving the Bulldogs a 3–0 lead. Later in the first quarter, Woodrow Dantzler threw a 10 yard touchdown pass to Matt Bailey, as the Tigers took a 7–3 lead into the second quarter.
In the second quarter, Luke McCown scored on an 11 yard touchdown run giving Louisiana Tech a 10–7 lead. Woodrow Dantzler threw a 53 yard touchdown pass to Roscoe Crosby giving Clemson a 14–10 lead. They would keep that lead through halftime.
In the third quarter, Dantzler threw a 5 yard touchdown pass to Ben Hall, increasing the Tigers lead to 21–10. Dantzler's fourth touchdown pass, a 62 yarder to Bernard Rambert gave the Tigers a 28–10 lead. Bernard Rambert scored on a 21 yard touchdown run to make it 35–10. Airese Curry added a 19 yard touchdown run, as the Tigers clawed to a 42–10 led at the end of 3 quarters.
In the fourth quarter, backup quarterback Willie Simmons threw a 57 yard touchdown pass to Derrick Hamilton, making the lead 49–10. Louisiana Tech would score on a 34 yard touchdown pass from McCown to Delwyn Daigre to cut the lead to 49–18. They scored once more on a 2 yard Joseph Smith run, making the final margin 49–24.