1966 Kansas Jayhawks football team represented the University of Kansas in the Big Eight Conference during the 1966 college football season. In their ninth and final season under head coach Jack Mitchell, the Jayhawks compiled a 2–7–1 record (0–6–1 against conference opponents), tied for last place in the Big Eight Conference, and were outscored by opponents by a combined total of 188 to 106.  They played their home games at  Memorial Stadium in Lawrence, Kansas.
The team's statistical leaders included Donnie Shanklin with 732 rushing yards, Halley Kampschroeder with 278 receiving yards and Bob Skahan with 299 passing yards.
Jerry Barnett and Bill Wohlford were the team captains. 
Date Opponent Site Result
September 17 Texas Tech * L 7–23
September 24 at Arizona * W 35–13
October 1 at Minnesota * W 16–14
October 8 at Iowa State L 7–24
October 15 Oklahoma Memorial Stadium Lawrence, KS L 0–35
October 22 at Oklahoma State L 7–10
October 29 at Kansas State T 3–3
November 5 No. 6 Nebraska Memorial Stadium Lawrence, KS ( rivalry) L 13–24
November 12 Colorado Memorial Stadium Lawrence, KS L 18–35
November 19 at Missouri L 0–7 *Non-conference game Rankings from AP Poll released prior to the game