Maryland was led by third-year head coach Jim Tatum, who had engineered one season turn-arounds at Maryland and previously Oklahoma. Missouri was coached by his former boss, Don Faurot, under whom Tatum had previous been an assistant coach for the U.S. Navy's Iowa Pre-Flight team. This game was the first in a six-game series between the former colleagues and would last for the remainder of Tatum's tenure at Maryland.
In the first quarter, Maryland scored on an 11-yard run by Bob Shemonski. Ed Modzelewski rushed for a three-yard touchdown in the second quarter, followed by a six-yard touchdown run by Shemonski again. The extra point kick was unsuccessful, however. In the final quarter, Phil Klein recorded Missouri's only score on a five-yard touchdown run.
Maryland recorded 282 yards of total offense, 266 yards of which came on the ground. Missouri recorded 267 yards total, with 100 rushing and 167 passing yards. Maryland achieved 11 first downs, compared with Missouri's 13. The Terrapins lost two fumbles for one yard while the Tigers lost five fumbles for five yards.