|1921 SMU Mustangs football|
|1921 record||1–6–1 (0–4–1 SWC)|
|Head coach||J. Burton Rix (5th year), W.A. Cunningham (interim)|
|Home stadium||Armstrong Field|
|1921 Southwest Conference football standings|
|Texas A&M †||3||–||0||–||2||6||–||1||–||2|
|† – Conference champion |
The 1921 SMU Mustangs football team was an American football team that represented Southern Methodist University (SMU) as a member of the Southwest Conference (SWC) during the 1921 college football season. In its fifth season under head coach J. Burton Rix, the team compiled a 1–6–1 record and was outscored by a total of 92 to 15. The team played its home games at Armstrong Field in University Park, Texas.
|October 1||Howard Payne*||W 3–0|
|October 12||Texas A&M||L 0–13|
|October 21||Austin*||L 7–17|||
|October 29||at Arkansas||Fort Smith, AR||L 0–14|
|November 5||Rice||L 0–7|
|November 12||TCU*||L 6–13|
|November 18||Southwestern (TX)*||T 0–0|
|November 24||at Baylor||L 0–28|
- "1921 SMU Mustangs Schedule and Results". SR/College Football. Sports Reference LLC. https://www.sports-reference.com/cfb/schools/southern-methodist/1921-schedule.html. Retrieved March 21, 2019.
- "Mustangs Walloped by Austin College". The Times (Shreveport, Louisiana): p. 8. October 21, 1921. https://www.newspapers.com/clip/31089462/the_times/.