The 1910 TCU Horned Frogs football team represented Texas Christian University (TCU) in the 1910 college football season. The Horned Frogs finished the season 2–6–1 overall. The team was coached by Kemp Lewis in his first and only year as head coach. They played their home games in Fort Worth, Texas after the school returned to the city to its original hometown after leaving for Waco, Texas.