2006 PapaJohns.com Bowl

The 2006 PapaJohns.com Bowl was the inaugural postseason college football match of the game, between the East Carolina Pirates and the South Florida Bulls at Legion Field in Birmingham, Alabama. East Carolina University represented Conference USA and the University of South Florida represented the Big East Conference. The game resulted in a 24–7 South Florida victory.

In the inaugural game, South Florida's Benjamin Williams scored the game's first points just over ninety seconds into the game as one of his two touchdowns on the day, and earned the game's MVP honors. Notably, South Florida had previously been a member of C-USA. Moreover, East Carolina's then head coach Skip Holtz, would later become USF head coach Jim Leavitt's successor following the 2009 season.