2003 Buffalo Bills season

The 2003 Buffalo Bills season was their 44th in the league. The team failed to improve upon their previous season's output of 8–8, instead finishing 6–10. The team missed the playoffs for the fourth consecutive season.

The Bills started the season strong, opening the season with a dominating 31–0 blowout of the New England Patriots (They would not win another game against the Patriots until 2011). It was their largest margin of victory in a season opener since 1992, and their first regular season shutout in four years. The Bills' second game was a convincing three-touchdown win over the Jacksonville Jaguars. But Buffalo lost seven of their next nine games, and finished the season with three consecutive losses. Ironically, the Bills' final game of the season was a 31–0 shutout loss to the New England Patriots – the reverse of the score by which the Bills beat New England in Week One.

Head coach Gregg Williams's contract was not renewed after the 2003 season, and he was replaced by Pittsburgh Steelers offensive coordinator Mike Mularkey in 2004.

Van Miller, the team's longtime play-by-play announcer, announced his retirement after week 2 of the season; his retirement took effect at the end of the season.

NFL Draft
The Bills traded away their first pick in the 2003 draft (#14 overall) to the New England Patriots for Drew Bledsoe in the previous draft. They obtained their first pick (#23 overall) from the Atlanta Falcons in exchange for Peerless Price. Though he was not drafted, Buffalo acquired running back Fred Jackson out of Coe College in 2003; Jackson went on to lead the league in all-purpose yardage in 2009.