List of Jacksonville Jaguars first-round draft picks

The Jacksonville Jaguars joined the National Football League (NFL) in 1995 as an expansion team, along with the Carolina Panthers. The Jaguars' first selection in the NFL draft as a team was Tony Boselli, an offensive tackle from the University of Southern California (USC). The team's most recent first round selection was Justin Blackmon, a wide receiver from the Oklahoma State University.

Every year during April, each NFL franchise seeks to add new players to its roster through a collegiate draft known as "the NFL Annual Player Selection Meeting", which is more commonly known as the NFL Draft. Teams are ranked in inverse order based on the previous season's record, with the worst record picking first, and the second worst picking second and so on. The two exceptions to this order are made for teams that appeared in the previous Super Bowl; the Super Bowl champion always picks 32nd, and the Super Bowl loser always picks 31st. Teams have the option of trading away their picks to other teams for different picks, players, cash, or a combination thereof. Thus, it is not uncommon for a team's actual draft pick to differ from their assigned draft pick, or for a team to have extra or no draft picks in any round due to these trades.

The Jaguars have never selected the number one overall pick in the draft, but they have selected the second overall pick twice. The team has selected players from Florida three times, and two times from USC and Tennessee.