2005 Iowa State Cyclones football team

The 2005 Iowa State Cyclones football team represented Iowa State University during the 2005 NCAA Division I-A football season. They played their home games at Jack Trice Stadium in Ames, Iowa. They participated as members of the Big 12 Conference in the North Division. The team was coached by head coach Dan McCarney and lost 24–27 to Texas Christian in the Houston Bowl.