October 10, 1920

! colspan="8" align="center" | October 10, 1920
 * colspan="8" align="center" | Week 3
 * - bgcolor="#efefef"
 * - align="center"
 * Columbus Panhandles (0-2-0) || 0 || Akron Pros (2-0-0) || 37 || Akron League Park
 * - align="center"
 * All-Buffalo (0-2-0) || 0 || Buffalo All-Americans (2-0-0) || 51 || Canisius Field
 * - align="center"
 * Toledo Maroons (0-1-0) || 0 || Canton Bulldogs (2-0-0) || 42 || Lakeside Park
 * - align="center"
 * Chicago Cardinals (0-0-1) || 0 || Chicago Tigers (0-0-1) || 0 || Cubs Park
 * - align="center"
 * Cleveland Tigers (0-0-1) || 0 || Dayton Triangles (1-0-1) || 0 || Triangle Park
 * - align="center"
 * Kewanee Walworths (0-1-0) || 7 || Decatur Staleys (2-0-0) || 25 || Staley Field
 * - align="center"
 * Cleveland Panthers (0-1-0) || 14 || Detroit Heralds (1-0-0) || 40 || Mack Park
 * - align="center"
 * Hammond Pros (0-1-0) || 0 || Rock Island Independents (3-0-0) || 26 || Douglas Park
 * - align="center"
 * Fort Porter (0-1-0) || 0 || Rochester Jeffersons (2-0-0) || 66 || Rochester Baseball Park
 * - bgcolor="#D0E7FF"