December 5, 1920

{| class="wikitable" cellpadding="14" border="2" ! colspan="8" align="center" | December 5, 1920
 * - bgcolor="#D0E7FF"
 * colspan="8" align="center" | Week 11
 * - bgcolor="#efefef"
 * - align="center"
 * Akron Pros (8-0-2) || 0 || Buffalo All-Americans (9-1-1) || 0 || Buffalo Baseball Park
 * - align="center"
 * Canton Bulldogs (6-3-2) || 0 || Washington Glee Club || 0 || New Haven, Connecticut
 * - align="center"
 * Chicago Cardinals (6-2-1) || 0 || Decatur Staleys (10-1-1) || 10 || Cubs Park
 * - align="center"
 * Columbus Wagner Pirates (0-1) || 0 || Columbus Panhandles (2-6-2) || 24 || Neil Park
 * - align="center"
 * Detroit Maroons (0-0-1) || 7 || Detroit Heralds (2-3-3) || 7 || Mack Park
 * - align="center"
 * Rochester Scalpers (0-2-1) || 0 || Rochester Jeffersons (6-3-2) || 0 || Exposition Park
 * - bgcolor="#D0E7FF"