List of Kansas City Chiefs first-round draft picks

The following is a complete list of players selected in the first round by the Kansas City Chiefs in the National Football League Draft. The list excludes the 1960 draft selections, due to the team's requirement to fill up their entire squad. Center E. J. Holub was the initial first round selection by made by the franchise.

From 1960 to 1962, the Chiefs were known as the Dallas Texans until their relocation to Kansas City, Missouri. The team participated in the American Football League's annual player draft from 1960 to 1966 until the beginning of the common draft in 1967 and the AFL's subsequent merger with the National Football League in 1970. Since 1970, the team has participated in the National Football League's annual player draft.

The Chiefs have only had the first overall selection in the draft once in franchise history, coming in 1963 when the team traded quarterback Cotton Davidson to the Oakland Raiders for the selection. The franchise has selected two players in the first round in the same year on five different occasions, coming in 1963, 1968, 1979, 1984, and 2008. The team has also traded away their first pick five times, coming in 1973, 1975, 1993, 2001, and 2004.

By position
Like most teams in the NFL, the Chiefs have never drafted a fullback, placekicker, or punter in the first round of the NFL Draft. Running backs are the most commonly selected by the Chiefs in the first round, with 10 coming since 1960.

By university
Four players have been chosen by the Chiefs from LSU in the first round of the NFL Draft, with three consecutive from 2007–2009, the most from any one university. Southern California, Iowa, Tennessee and Penn. State have all contributed three players to the Chiefs in the first round of the draft, all tied for second-most from one school.