2016 Case Western Reserve Spartans football team

The 2016 Case Western Reserve Spartans football team represented Case Western Reserve University of Cleveland, Ohio, during the 2016 NCAA Division III football season. The team was coached by 13th-year coach Greg Debeljak and played its home games at DiSanto Field. The Spartans finished 2nd in the Presidents' Athletic Conference with a 7–1 record and tied for 1st in the University Athletic Association with a 2–1 record.