October 3, 1920

! colspan="8" align="center" | October 3, 1920
 * - bgcolor="#D0E7FF"
 * colspan="8" align="center" | Week 2
 * - bgcolor="#efefef"
 * - align="center"
 * Wheeling Stogies (0-1-0) || 0 || Akron Pros (1-0-0) || 43 || Akron League Park
 * - align="center"
 * West Buffalo (0-1-0) || 6 || Buffalo All-Americans (1-0-0) || 32 || Canisius Field
 * - align="center"
 * Pitcairn Quakers (0-1-0) || 0 || Canton Bulldogs (1-0-0) || 48 || Lakeside Park
 * - align="center"
 * Columbus Panhandles (0-1-0) || 0 || Dayton Triangles (1-0-0) || 14 || Triangle Park
 * - align="center"
 * Moline Universal Tractors (0-1-0) || 0 || Decatur Staleys (1-0-0) || 20 || Staley Field
 * - align="center"
 * Muncie Flyers (0-1-0) || 0 || Rock Island Independents (2-0-0) || 45 || Douglas Park
 * - align="center"
 * All-Buffalo (0-1-0) || 0 || Rochester Jeffersons (1-0-0) || 10 || Rochester Baseball Park
 * - bgcolor="#D0E7FF"