1972 Iowa State Cyclones football team

The 1972 Iowa State Cyclones football team represented Iowa State University in the Big Eight Conference during the 1972 NCAA University Division football season. In their fifth and final year under head coach Johnny Majors, the Cyclones compiled a 5–6–1 record (2–3–1 against conference opponents), finished in seventh place in the conference, and outscored opponents by a combined total of 319 to 238. They played their home games at Clyde Williams Field in Ames, Iowa.

George Amundson and Matt Blair were the team captains.