List of Clemson Tigers in the NFL Draft

The Clemson University Tigers football team has had 211 players drafted into the National Football League (NFL) since the league began holding drafts in 1936. The highest that a Tiger has ever been drafted is fourth overall, which has happened on two occasions: Banks McFadden in 1939 and Gaines Adams in 2007. The Pittsburgh Steelers and New York Giants have drafted the most Tar Heels with sixteen and fifteen, respectively. The only current NFL franchises that have not selected a Clemson Tiger are the Arizona Cardinals, Baltimore Ravens, Carolina Panthers, and Houston Texans.

Each NFL franchise seeks to add new players through the annual NFL Draft. The draft rules were last updated in 2009. The team with the worst record the previous year picks first, the next-worst team second, and so on. Teams that did not make the playoffs are ordered by their regular-season record, with any remaining ties broken by strength of schedule. Playoff participants are sequenced after non-playoff teams, based on their round of elimination (wild card, division, conference, and Super Bowl).

Before the merger agreements in 1966, the American Football League (AFL) operated in direct competition with the NFL and held a separate draft. This led to a massive bidding war over top prospects between the two leagues, along with the subsequent drafting of the same player in each draft. As part of the merger agreement on June 8, 1966, the two leagues held a multiple round "Common Draft". Once the AFL officially merged with the NFL in 1970, the "Common Draft" simply became the NFL Draft.

Twenty-two Tigers drafted in the first round of the NFL Draft, with the most recent being C. J. Spiller in 2010. The single first round of the NFL Draft with the most Tigers selected was 1979 and 1982 with two players. Of the Tar Heels selected in the NFL Draft, fourteen have been selected to a Pro Bowl, nineteen have been a member of a Super Bowl winning team; four have achieved both. The most Tigers selected in a single NFL Draft is nine, in 1983.