1980 Buffalo Bills season

The 1980 Buffalo Bills season was the 21st season for the club in the National Football League.

AFC Playoff
With 2:08 left in the game, Chargers quarterback Dan Fouts threw the 50-yard winning touchdown pass to receiver Ron Smith to defeat the Bills, 20–14.

Notable events
In Week 15, the Bills became the thirty-fourth team to score only a safety in a full game. It was the first occurrence of this since the San Diego Chargers against the Pittsburgh Steelers in the last game of the 1972 season, and there have been only two since, by the 1983 Minnesota Vikings and the 1993 Cincinnati Bengals.