List of St. Louis Rams first-round draft picks

The St. Louis Rams, a professional American football team based in St. Louis, Missouri, joined the National Football League (NFL) as Cleveland Rams in 1937. The Rams began playing in 1936 as a charter member of the second American Football League. Although the NFL granted membership to the same owner, the NFL considers it a separate entity. In 1946, Rams' owner Dan Reeves, fed up with poor attendance at Cleveland Stadium moved the Rams to Los Angeles, and the team played there from 1946–1994. The Rams moved to St. Louis in 1995 and renamed the team St. Louis Rams.

The Rams first participated in the 1938 NFL Annual Player Selection Meeting, more commonly known as the NFL Draft. The Rams did have a 1937 pick, but it was picked by the NFL for an expansion team and later the Rams were later admitted into the league before the 1937 season. Every year during April, each NFL franchise seeks to add new players to its roster through the NFL Draft. Teams are ranked in inverse order based on the previous season's record, with the worst record picking first, and the second–worst picking second and so on. The two exceptions to this order are made for teams that appeared in the previous Super Bowl; the Super Bowl champion always picks 32nd, and the Super Bowl loser always picks 31st. Teams have the option of trading away their picks to other teams for different picks, players, cash, or a combination thereof. Thus, it is not uncommon for a team's actual draft pick to differ from their assigned draft pick, or for a team to have extra or no draft picks in any round due to these trades.

The Rams' first selection as an NFL team was Johnny Drake, a fullback from Purdue in 1937. The Rams have selected the number one overall five times, drafting Corbett Davis in 1938, Billy Cannon in 1960, Terry Baker in 1963, Orlando Pace in 1997, and Sam Bradford in 2010 The Rams have drafted second overall seven times and the third overall two times. Five eventual Hall of Famers were selected by the Rams: Elroy "Crazylegs" Hirsch, Merlin Olsen, Tom Mack, Jack Youngblood, and Eric Dickerson. The team's most recent first round selection was Sam Bradford, a quarterback from Oklahoma.